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目的：探讨和研究两种剂量低分子质量肝素治疗急性脑梗死的临床效果和安全性。方法：采用随机分组分为大剂量组、小剂量组和对照组，大剂量组、小剂量组方法相同，均皮下注射方法，大剂量组每隔１２小时１次，小剂量组每天１次，每次１支（１００００ＡＸａＩＣＵ），对照组采用维脑路通１．０静滴，每天一次，三组均连用１０天，观察治疗前及治疗后５、１０． １５、３０天患者临床神经功能缺损评分和头颅ＣＴ或ＭＲＩ变化，生化指标并作出疗效评价。结果：ＬＭＷＨ大剂量组、小剂量组皮下注射治疗急性脑梗死显效率和有效率明显高于对照组；而大剂量组又明显高于小剂量组；ＬＭＷＨ大剂量组、小剂量组对出凝血各项指标影响较小，具有明显恢复神经功能缺损作用，疗效迅速，显著。结论：ＬＭＷＨ大剂量组、小剂量组治疗急性脑梗死是安全、稳定、有效的，采用大剂量并不增加副作用。是一种具有广阔应用前景的新型抗凝剂。
Objective: To investigate and study the clinical effects and safety of two doses of low molecular weight heparin in the treatment of acute cerebral infarction. Methods: The rats were randomly divided into high dose group, low dose group and control group. The methods of high dose group and low dose group were the same. All of them were subcutaneously injected once every 12 hours in high dose group and once in small dose group, Each time a (10000AXaICU), the control group with Venoruton 1.0 intravenous infusion once a day, the three groups were used for 10 days, observed before and after treatment 5,10. 15,30 days patients with clinical neurological deficit score and head CT or MRI changes, biochemical indicators and make a curative effect evaluation. Results: The effective rate and effective rate of LMWH high-dose group and low-dose subcutaneous injection in treating acute cerebral infarction were significantly higher than those in control group, while those in high-dose group and low-dose group were significantly higher than those in low-dose group. In LMWH high-dose group and low-dose group, The indicators have a smaller impact, with significant recovery of neurological deficits, rapid and significant effect. Conclusion: The LMWH high dose group and the low dose group are safe, stable and effective in treating acute cerebral infarction. The high dose of LMWH does not increase the side effects. Is a new type of anticoagulant with broad application prospects.