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目的：探讨轻度一氧化碳中毒（ＣＯＰ）急性期的脑循环血液动力学指标（ＣＶＤＩ）变化及其临床意义。方法：采用脑循环血液动力学检测仪，选择急性轻度ＣＯＰ患者（４６例，ＣＯＰ组）进行ＣＶＤＩ检测，并与相应的正常参考值（对照组）对照。２３／４６（５２．２％）例ＣＯＰ患者同时进行常规脑电图（ＥＥＧ）描记。分别将ＣＯＰ组中的ＥＥＧ结果与ＣＶＤＩ以及两组间ＣＶＤＩ值进行对比分析。结果：ＣＯＰ组中，２３例ＥＥＧ结果：１５／２３（６５．２％）例ＥＥＧ异常；８／２３（３４．８％）例ＥＥＧ正常。但与相应的正常参考值比较，此２３例患者的 ＣＶＤＩ值均有２项以上指标异常。两组间ＣＶＤＩ比较，ＣＯＰ组脑血流量及血流速度均明显低于对照组（Ｐ＜０．０１）；脑循环外周阻力和临界压均明显高于对照组，脑血流自身调节机能指标下降（Ｐ＜０．０１）。结论：急性轻度 ＣＯＰ即可伴发 ＣＶＤＩ的异常改变。
Objective: To investigate the changes of cerebral circulation hemodynamics (CVDI) and its clinical significance in the acute phase of mild carbon monoxide poisoning (COP). Methods: Cerebral circulation hemodynamic detector was used to detect CVDI in COPD patients (46 cases, COP group) and compared with the corresponding normal reference value (control group). 23/46 (52.2%) cases of COP patients with conventional electroencephalography (EEG) tracings. The EEG results in the COP group were compared with the CVDI and the CVDI values between the two groups respectively. Results: In the COP group, 23 cases of EEG results showed 15/23 (65.2%) cases of EEG abnormalities and 8/23 (34.8%) cases of normal EEG cases. However, compared with the corresponding normal reference value, all of the 23 patients had abnormality of more than 2 indexes in CVDI value. Cerebral blood flow and blood flow velocity in COP group were significantly lower than those in control group (P <0.01). The peripheral resistance and critical pressure in cerebral circulation were significantly higher than those in control group Decreased (P <0.01). Conclusion: Acute mild COP can be associated with abnormal changes of CVDI.