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目的:研究复方美登木片对实验性大鼠乳腺增生病的防治作用及其机制。方法:采用肌肉注射雌二醇和黄体酮法造成大鼠乳腺增生模型。结果:复方美登木片0.58g/kg、1.16g/kg、2.33g/kg能够明显减小雌二醇加黄体酮所致乳腺增生大鼠的乳房直径、乳头高度,减轻乳腺重量;能够降低乳腺增生程度,明显减少乳腺小叶数、小叶内腺泡数、腔内分泌物;此外,对性激素水平有明显的影响,复方美登木片1.16g/kg、2.33g/kg能够显著降低大鼠血清雌二醇(E2)、催乳素(PRL)水平,提高孕酮(P)水平,其起效剂量及剂量范围分别为:0.58g/kg,0.58～2.33g/kg。结论:复方美登木片对实验性大鼠乳腺增生病有明显的防治作用。
Objective: To study the preventive and therapeutic effects and the mechanisms of compound Menteng wood tablets on experimental rat mammary gland hyperplasia. Methods: The model of mammary gland hyperplasia was induced by intramuscular injection of estradiol and progesterone. Results: 0.58 g / kg, 1.16 g / kg and 2.33 g / kg of compound bengal wood chips could obviously reduce the breast diameter, the height of the nipple and the mammary gland weight of mammary gland hyperplasia rats induced by estradiol and progesterone; In addition, the level of sex hormones have a significant impact, compound Metallurgical 1.16g / kg, 2.33g / kg can significantly reduce the serum estradiol in rats Alcohol (E2) and prolactin (PRL), and raise the level of progesterone (P). The effective dosage and dosage ranges of the two preparations were 0.58g / kg and 0.58 ~ 2.33g / kg, respectively. Conclusion: The compound Metallurgical wood chips have significant preventive and therapeutic effects on experimental rat mammary gland hyperplasia.