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目的探讨高氧液作为基础溶液,进行腹腔灌洗,治疗急性继发性腹膜炎疗效及作用机制。方法将成年SD大鼠随机分为3组,建立急性继发性腹膜炎模型(CLP模型),分别进行抗生素灌洗,抗生素+高氧液灌洗以及非灌洗3组对照。术后分别于6、12、18h抽血,测量中性粒细胞水平以及血清TNF-α,IL-6水平,以评价腹膜炎炎症反应严重程度。结果TNF-α水平在3组间差异均有统计学意义;IL-6水平在灌洗和非灌洗组间差异有统计学意义;中性粒细胞百分比在3组间差异均无统计学意义。结论高氧液作为基础溶液在急性继发性腹膜炎腹腔灌洗治疗中有一定的治疗效果。
Objective To investigate the efficacy and mechanism of hyperoxic liquid as a basic solution for peritoneal lavage in the treatment of acute secondary peritonitis. Methods Adult SD rats were randomly divided into three groups. Acute secondary peritonitis model (CLP model) was established. Antibiotic lavage, antibiotic + hyperoxic liquid lavage and non-lavage three groups were compared. Blood samples were collected at 6, 12 and 18 hours after operation, respectively. Neutrophil levels, serum TNF-α and IL-6 levels were measured to evaluate the severity of peritonitis. Results There was significant difference in TNF-α levels among the three groups. The level of IL-6 was significantly different between lavage and non-lavage groups. There was no significant difference in the percentage of neutrophil between the three groups . Conclusion Hypoxic solution as a basic solution in the treatment of acute peritonitis peritoneal lavage have a certain therapeutic effect.