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目的探讨替勃龙片联合替硝唑泡腾片治疗老年性阴道炎患者的疗效和安全性。方法选取2012年4月至2015年10月江苏省淮安市华东妇产医院收治的60例老年性阴道炎患者作为研究对象,按照随机数字表法分为单用组和联合组,各30例,单用组患者以替硝唑泡腾片治疗,联合组患者则在单用组基础上联合替勃龙片进行治疗,对比两组患者的疗效和不良反应。结果治疗后,联合组患者治疗总有效率明显高于单用组,差异有统计学意义(P<0.05);并且,联合组患者的阴道炎症状评分、阴道脱落细胞成熟指数(MI)、促卵泡激素(FSH)、雌二醇水平均明显优于单用组,差异均有统计学意义(均P<0.05)。结论老年性阴道炎患者采取替勃龙片联合替硝唑泡腾片治疗效果明显,安全性高。
Objective To investigate the efficacy and safety of tibolone tablets combined with tinidazole effervescent tablets in the treatment of senile vaginitis. Methods Sixty elderly patients with senile vaginitis admitted from Huadong Maternity Hospital of Huaian City, Huaian City, Jiangsu Province from April 2012 to October 2015 were selected as study subjects and divided into single group and combination group according to random number table method, 30 cases in each group, Patients in the single group were treated with tinidazole effervescent tablets. The patients in the combination group were treated with tibolone tablets on the basis of the single group. The curative effect and adverse reactions of the two groups were compared. Results After treatment, the total effective rate of the combination group was significantly higher than that of the single use group (P <0.05). And the scores of vaginitis symptoms, vaginal exfoliated cell maturation index (MI) Follicle-stimulating hormone (FSH) and estradiol levels were significantly better than those of single use group (all P <0.05). Conclusion The treatment of senile vaginitis patients taking tibolone tablets combined with tinidazole effervescent tablets is effective and safe.