选择性5-羟色胺再吸收抑制剂如氟西汀、舍曲林、帕罗西汀、氟伏沙明、西酞普兰等常用于治疗各种因素引起的抑郁症,随着使用人数的逐渐增多,所暴露的不良反应也增多。通过检索国外相关文献,发现该类药物暴露其不良反应有时间先后顺序,主要为最早短暂的效应、持续效应、与其他药物或食物相互作用所产生的效应、延迟效应和停药效应。医护人员和患者应警惕该类药物的迟发和停药不良反应,避免使用与其有不良相互作用的其他药物和食物。 Selective serotonin reuptake inhibitors such as fluoxetine, sertraline, paroxetine, fluvoxamine, citalopram and other commonly used in the treatment of depression caused by various factors, as the number of users gradually increased, Exposure to adverse reactions also increased. Through retrieving relevant literature from other countries, it is found that the time sequence of the adverse reactions of such drugs is mainly the earliest transient effect, the persistent effect, the effect caused by the interaction with other drugs or foods, the delay effect and the withdrawal effect. Health care workers and patients should be alert to the delay and withdrawal of such drugs adverse reactions, to avoid the use of adverse drug interactions with other drugs and food.