成人急性非粒细胞性白血病患者中枢神经系统早期受累

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预防性治疗可防止中枢神经系统(CNS)白血病复发,明显地延长急性淋巴细胞性白血病(ALL)患儿的生存期,甚至可能获得治愈,预防性CNS治疗似乎可改进完全缓解的成人患者生存期。作者研究1972~1976年间连续收治的47例成人非粒细胞白血病(ANML)患者,其中,40例ALL,6例急性伯基特样白血病(ABLL),2例急性未分化型白血病(AUL)。患者年龄为15~60岁,均应用同一种治疗方案(OPAL)。当患者达到完全缓解的初期,给予CNS Prophylactic treatment may prevent the relapse of central nervous system (CNS) leukemia, significantly prolong the survival of children with acute lymphoblastic leukemia (ALL), and may even be cured. Prophylactic CNS treatment seems to improve the survival of adult patients with complete remission . The authors studied 47 consecutive patients with non-myelogenous leukemia (ANML) who were admitted to the hospital between 1972 and 1976, of whom 40 were ALL, 6 were acute Burkitt’s leukemia (ABLL), and 2 were acute undifferentiated leukemia (AUL). Patients aged 15 to 60 years old, are using the same treatment (OPAL). The CNS was given when the patient reached complete remission
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