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目的 探讨乳腺肿块细针穿刺端粒酶活性检测在乳腺癌术前诊断中的临床应用价值。方法 对 85例乳腺肿块病人进行细针穿刺 ,对穿刺细胞分别用端粒重复扩增法 (TRAP)进行端粒酶活性检测和光镜细胞检查。以术后石蜡病理切片结果为最终标准 ,分别对两种检测方法在术前诊断乳腺癌方面的灵敏度、特异性和约登指数进行了比较。结果 术前端粒酶活性检测同穿刺细胞学相比 ,特异性分别为 73 9%和 82 6 % (P >0 0 5 ) ,差异无显著性 ;灵敏度分别为 91 9%和 6 4 5 % (P <0 0 5 ) ,约登指数分别为 6 5 8%和 47 1% (P <0 0 5 ) ,差异有显著意义。结论 乳腺肿块穿刺端粒酶活性检测在乳腺癌术前诊断中具有较大的应用价值。
Objective To investigate the clinical value of fine-needle aspiration telomerase activity in the diagnosis of preoperative breast cancer. Methods Totally 85 cases of breast masses were treated with fine needle aspiration and telomerase activity and light microscopy were performed on the punctured cells by telomeric repeat amplification (TRAP). The postoperative paraffin sections were used as the final standard to compare the sensitivity, specificity and Youden index of the two methods in preoperative diagnosis of breast cancer. Results The preoperative telomerase activity was 73 9% and 82 6%, respectively, with no significant difference as compared with the biopsy cytology; the sensitivity was 91 9% and 64 5% respectively (P <0.05), and the Youden index was 65.8% and 47.1%, respectively (P <0 05), the difference was significant. Conclusion Detection of telomerase activity in breast lumps has a great value in the preoperative diagnosis of breast cancer.