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癫痫猝死(sudden unexpected deathin epilepsy,SUDEP)是癫痫患者最重要的直接与癫痫相关的死亡原因。其潜在病理机制尚未阐明,但癫痫发作时和发作间期的心律失常,电解质紊乱,致心律失常药物或癫痫电活动通过自主神经系统向心脏的传导,很可能与SUDEP的发病机理有关。引人注意的是,临床和实验数据都显示体力活动可以降低癫痫发作频率,并促进癫痫患者的心血管健康。基于上述情况,本文综述了体育锻炼可能预防SUDEP发生的相关文献内容。
Sudden unexpected death in epilepsy (SUDEP) is the most important epilepsy related cause of death in epilepsy patients. Its underlying pathological mechanism has not yet been elucidated, but the arrhythmia and electrolyte imbalance in seizure and interictal period, the conduction of arrhythmic drugs or epileptic activity through the autonomic nervous system to the heart may be related to the pathogenesis of SUDEP. Strikingly, both clinical and experimental data show that physical activity can reduce the frequency of seizures and promote cardiovascular health in epilepsy patients. Based on the above situation, this article summarizes the relevant literature that physical exercise may prevent the occurrence of SUDEP.