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为保证临床用药安全和有效,临床实验室常需要进行治疗药物的监测工作,以便控制用药剂量,制定合理的给药方案,使之既可达到预期的疗效,又可预防药物中毒的发生。当所用药物的治疗指数低、安全范围窄、毒副作用大的情况下,这项工作的开展尤为重要。由于临床检样(血、尿等)的复杂性,并可能存在其它组分(如抗凝剂或同时合并应用其它药物等)的干扰,所以要求监测方法必须专属性高;此外,因超剂量或误用药而就诊者往往是在急症时间,所以监测方法必须简便易行,并能迅
In order to ensure the safety and effectiveness of clinical medication, clinical laboratories often need to monitor the treatment of drugs in order to control the dose of medication, to develop a reasonable dosing regimen to achieve the desired effect, but also to prevent drug poisoning. This work is particularly important when the therapeutic index of the drug used is low, the safety margin is narrow, and the side effects are high. Due to the complexity of clinical samples (blood, urine, etc.), and may interfere with other components (such as anticoagulants or concurrent use of other drugs, etc.), so the monitoring method must be highly specialized; In addition, due to overdosage Or misuse of medication and the doctor is often in emergency situations, monitoring methods must be easy and quick