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目的探讨妊娠期肝内胆汁淤积症(ICP)肝功能、白细胞介素-6(IL-6)、IL-8、IL-10及肿瘤坏死因子-α(TNF-α)的变化及其相互关系。方法选取58例ICP患者为研究对象,另选取50例正常妊娠妇女为对照组,采用ELISA法测定两组血清IL-6、IL-8、IL-10、TNF-α水平,应用全自动生化分析仪测定两组肝功能指标。结果 ICP组患者血清IL-6、IL-8、IL-10、TNF-α、TBA、AST、ALT水平显著高于对照组,差异有统计学意义(P<0.05);ICP组中重度患者血清IL-6、IL-8、IL-10、TNF-α、TBA、AST、ALT水平高于轻度患者,差异有统计学意义(P<0.05)。经Pearson相关因素分析显示,IL-6、IL-8、TNF-α与TBA、AST、ALT水平均呈正相关(P<0.05),IL-10与TBA、AST、ALT水平呈负相关(P<0.05)。结论炎症细胞因子水平失衡及肝功能损害可能与ICP患者病情发生及不良妊娠结局有密切的关系,通过测定孕妇细胞炎症因子及肝功能指标,对预测患者不良妊娠结局、改善患者预后具有积极的作用。
Objective To investigate the changes of liver function, interleukin-6 (IL-6), IL-8, IL-10 and tumor necrosis factor-α (TNF- α) in patients with intrahepatic cholestasis of pregnancy . Methods Fifty-eight patients with ICP were enrolled in this study. Fifty normal pregnant women were selected as the control group. Serum levels of IL-6, IL-8, IL-10 and TNF-α were measured by ELISA. Instrument measured two groups of liver function indicators. Results The levels of serum IL-6, IL-8, IL-10, TNF-α, TBA, AST and ALT in ICP group were significantly higher than those in control group (P <0.05) The levels of IL-6, IL-8, IL-10, TNF-α, TBA, AST and ALT were significantly higher than those of mild patients (P <0.05). The Pearson correlation analysis showed that the levels of IL-6, IL-8 and TNF-α were positively correlated with TBA, AST and ALT (P <0.05), and negatively correlated with TBA, AST and ALT 0.05). Conclusions The imbalance of inflammatory cytokines and liver dysfunction may be closely related to the occurrence of patients with ICP and the outcome of adverse pregnancy. The determination of inflammatory cytokines and liver function in pregnant women may play an active role in predicting adverse pregnancy outcomes and improving the prognosis of patients .