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目的系统评价加巴喷丁治疗尿毒症患者皮肤瘙痒和改善睡眠质量的有效性和安全性。方法检索Pub Med、Cochrane Library、EMbase、EBSCO、中国知网、万方数据和维普数据,截至2016-04-15。纳入加巴喷丁治疗尿毒症皮肤瘙痒的研究,试验组予以加巴喷丁治疗,对照组予以安慰剂或抗组胺药物等治疗。用Rev Man 5.3软件对皮肤瘙痒缓解率、皮肤瘙痒评分以及睡眠质量评分进行Meta分析。结果共纳入13个研究,共计657例患者。Meta分析结果显示:加巴喷丁较安慰剂或抗组胺药物更利于提高总有效率,降低皮肤瘙痒评分和睡眠质量评分,差异均有统计学意义(P<0.001)。结论加巴喷丁能有效地缓解尿毒症皮肤瘙痒,改善睡眠质量,提高尿毒症患者生活质量,且无严重药物不良反应。
Objective To systematically evaluate the efficacy and safety of gabapentin in the treatment of pruritus and improve the quality of sleep in uremic patients. Methods PubMed, Cochrane Library, EMbase, EBSCO, CNK, Wanfang Data and VGP data access Inclusion of gabapentin in the treatment of uremic pruritus, gabapentin in the test group and placebo or antihistamine in the control group. Meta-analysis was performed using Rev Man 5.3 software on the rate of itch relief, the pruritus score, and the sleep quality score. Results A total of 13 studies were included for a total of 657 patients. Meta analysis showed that gabapentin was more effective than placebo or antihistamine in increasing total effective rate, reducing pruritus score and sleep quality score (all P <0.001). Conclusion Gabapentin can effectively relieve the pruritus of uremic skin, improve the quality of sleep, improve the quality of life of patients with uremia, and no serious adverse drug reactions.