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高迁移率族蛋白-1(HMGB1)是广泛存在于真核细胞内高度保守的非组蛋白染色体蛋白。研究表明HMGB1可由巨噬细胞等主动分泌或由坏死细胞被动释放到细胞外基质内。作为晚期炎症因子参与脓毒症、关节炎等病理生理反应过程,并认为它有可能是肿瘤坏死因子α(TNFα)、白细胞介素-1(IL-
High mobility group boxin-1 (HMGB1) is a non-histone chromosomal protein that is highly conserved within eukaryotes. Studies have shown that HMGB1 can be actively secreted by macrophages or the like and passively released into the extracellular matrix by necrotic cells. As a late inflammatory cytokine involved in sepsis, arthritis and other pathophysiological processes, and that it may be tumor necrosis factor alpha (TNFα), interleukin-1 (IL-