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目的对2008-2009年我院早孕期唐氏联合筛查的妊娠对象出生后妊娠结局进行回顾性随访。方法 2008-2009年,我院完成单胎妊娠早孕期唐氏联合筛查共计5218例。对所有病例全部进行随访,随访方式主要以病案追踪及电话随访为主。随访内容主要包括胎儿宫内发育情况及新生儿出生后健康状况。采用切割值1/250,对阳性筛查对象与阴性筛查对象的妊娠结局进行比较分析。结果 5218例筛查对象中,151例(2.9%)孕妇筛查阳性,127例(84.1%)成功随访。127例阳性筛查对象与3700例阴性筛查对象进行比较,阳性对象存在显著的不良妊娠结局高风险(不良妊娠结局16.5%vs 1.6%,P<0.001;染色体异常8.7%vs 0.1%,P<0.001;结构畸形6.3%vs 0.9%,P<0.001;较早期自然流产1.6%vs 0.1%,P<0.001)。结论筛查阳性妊娠对象,除了存在胎儿染色体异常高风险外,胎儿结构畸形和自然流产的风险亦较高。
Objective To retrospectively analyze the postnatal pregnancy outcome of Down’s syndrome screening combined with Down’s syndrome in our hospital from 2008 to 2009. Methods From 2008 to 2009, our hospital completed a total of 5218 cases of Down’s syndrome combined with singleton pregnancy in the first trimester. All cases were followed up, follow-up mainly to track cases and telephone follow-up. Follow-up mainly includes intrauterine development and neonatal health status after birth. The cut value of 1/250 was used to compare the pregnancy outcomes of positive and negative screening subjects. Results Of the 5218 screening subjects, 151 (2.9%) pregnant women were screened positive and 127 (84.1%) were successfully followed up. In 127 positive screening subjects compared with 3700 negative screening subjects, positive subjects had a significant risk of adverse pregnancy outcomes (adverse pregnancy outcome 16.5% vs 1.6%, P <0.001; chromosomal abnormalities 8.7% vs 0.1%, P < 0.001; structural abnormalities 6.3% vs 0.9%, P <0.001; early spontaneous abortion 1.6% vs 0.1%, P <0.001). Conclusion In addition to the high risk of fetal chromosomal abnormalities, there is a higher risk of fetal structural deformity and spontaneous abortion.