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本文观察了兼有α_1受体阻断作用的β受体阻断剂柳胺苄心定(labetalol,简称Lab)对急性心肌梗塞家兔心肌血流量(放射性微球法),梗死范围及左室功能的影响,并与心得安比较。结果表明:小剂量Lab(1mg/kg)主要显示β受体阻断效应,它能减慢心率,降低心肌耗氧量,降低非梗死区心肌血流量,缩小梗死范围,其效应与心得安相似,且能改善左室舒缩功能;大剂量Lab(5mg/kg),能同时阻断α_1和β受体,它能降低动脉血压,相对增加各区心肌血流量,显著减少心肌耗氧量,缩小梗死范围。结果提示:在急性心肌梗塞治疗中,同时阻断α_1和β受体较单纯阻断β受体优越。
In this paper, we observed the effects of beta receptor antagonist α1 receptor blocker (LAB) on myocardial blood flow (radioactive microsphere), infarct size and left ventricle in rabbits with acute myocardial infarction Functionality and comparison with empathy. The results showed that the low dose of Lab (1mg / kg) mainly showed the effect of β-receptor blockade, which could slow heart rate, decrease myocardial oxygen consumption, decrease myocardial blood flow in non-infarcted area, and reduce the infarct size. , And can improve left ventricular systolic and diastolic function; high dose of Lab (5mg / kg), which can block both α_1 and β receptors, it can reduce arterial blood pressure, relatively increase myocardial blood flow in each area, significantly reduce myocardial oxygen consumption, Infarct range. The results suggest that, in the treatment of acute myocardial infarction, while blocking α 1 and β receptors than simply blocking the β receptor superior.