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目的:本文对P120ctn蛋白水平在乳腺癌组织中表达和基因扩增情况进行研究。方法:通过免疫组化法和荧光原位杂交法对乳腺癌组织进行检测。结果:P120ctn在乳腺浸润性导管癌和浸润性小叶癌中表达部位不同;P120ctn基因在16例乳腺癌中只有1例扩增。结论:P120ctn胞膜表达为乳腺浸润性导管癌,胞浆表达为乳腺浸润性小叶癌;P120ctn基因在乳腺癌中扩增不明显。
Objective: In this paper, P120ctn protein levels in breast cancer tissue expression and gene amplification studies. Methods: Breast cancer tissues were detected by immunohistochemistry and fluorescence in situ hybridization. Results: The expression of P120ctn was different between invasive ductal carcinoma and invasive lobular carcinoma. Only P1pctn gene was amplified in 16 cases of breast cancer. Conclusion: The membrane expression of P120ctn is invasive ductal carcinoma of the breast, cytoplasm is expressed in breast lobular carcinoma, and the amplification of P120ctn gene is not obvious in breast carcinoma.