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[目的]观察二甲双胍片联合健脾调脂化瘀方治疗肥胖症并非酒精性脂肪性肝炎的临床疗效。[方法]临床收集肥胖症并非酒精性脂肪性肝炎患者109例,随机分为治疗组和对照组,治疗组55例,对照组54例。对照组给予二甲双胍片、多烯磷脂酰胆碱胶囊口服治疗,治疗组给予二甲双胍片联合中药健脾调脂化瘀方口服治疗,连续12周。观察2组患者治疗前后临床症状、体征、体质指数(BMI)及肝脏超声的变化,检测血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)水平的变化。[结果]治疗组总有效率为90.9%(40/55),对照组总有效率为75.9%(41/54),2组比较差异有统计学意义(P〈0.05)。与治疗前相比较,对照组患者血清ALT、AST、TG、TC水平降低(P〈0.05或P〈0.01),HDL-C水平升高(P〈0.05),LDL-C水平无明显变化(P>0.05);治疗组患者血清ALT、AST、TG、TC、LDL-C水平明显降低(P〈0.01),HDL-C水平明显升高(P〈0.01)。与对照组比较,治疗组患者血清ALT、AST、TG、TC、LDL-C水平降低,血清HDL-C水平升高,均优于对照组(P〈0.05)。[结论]二甲双胍片联合健脾调脂化瘀方治疗肥胖症并非酒精性脂肪性肝炎,具有良好的临床疗效。
[Objective] To observe the clinical efficacy of metformin tablets combined with Jianpi Tiaozhi Huayu Recipe in the treatment of obesity is not non-alcoholic steatohepatitis. [Method] 109 cases of obesity who were not obese with alcoholic steatohepatitis were randomly divided into treatment group and control group, with 55 cases in treatment group and 54 cases in control group. The control group was given metformin tablets, polyene phosphatidylcholine capsules oral treatment, the treatment group was given metformin tablets combined with Chinese medicine spleen Tiaozhi Huayu Fang oral treatment for 12 weeks. The changes of clinical symptoms, signs, body mass index (BMI) and liver ultrasound before and after treatment were observed in two groups. Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride ), Total cholesterol (TC), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C) levels. [Results] The total effective rate was 90.9% (40/55) in the treatment group and 75.9% (41/54) in the control group. The difference between the two groups was statistically significant (P <0.05). The levels of ALT, AST, TG and TC in the control group decreased (P <0.05 or P <0.01), HDL-C level increased (P <0.05) > 0.05). Serum levels of ALT, AST, TG, TC and LDL-C in the treatment group were significantly decreased (P <0.01) and HDL-C levels were significantly increased (P <0.01). Compared with the control group, serum ALT, AST, TG, TC and LDL-C in the treatment group decreased and serum HDL-C level increased, which were better than the control group (P <0.05). [Conclusion] Metformin tablets combined with Jianpi Tiaozhi Huayu Recipe in the treatment of obesity is not alcoholic steatohepatitis and has good clinical curative effect.