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OBJECTIVE The purpose of this study was to evaluate the quality of life (QOL) in Chinese middle-aged male patients with gastric carcinoma after total gastrectomy, to investigate the factors affecting their QOL, and to Study the effectiveness of nursing intervention. METHODS Structured questionnaire (EORTC QLQ-C30) was used among 162 middle-aged male patients after total gastrectomy (the patients finished the whole process of chemotherapy, and returned home, and society) for data collection and reevaluate the patients' quality of life with 2 months nursing intervention. RESULTS The patient's quality of life was related to their education level, economic condition, family support, and pathological staging. This study showed that patients got higher scores in Functional scales (except for CF), and lower scores in Symptom scales and single items (except for FI) after receiving intervention than before it was received before. CONCLUSION The study revealed that the QOL in middleaged male patients after total gastrectomy was worse when there was inadequate attention. After implementing pertinent nursing intervention implementing, patients' mental attitude and negative behavior were improved, and their QOL was enhanced after returning home and into society.