T淋巴细胞是机体适应性免疫系统的核心组成细胞,它所介导的免疫应答在机体清除入侵病原体或病变细胞的过程中发挥着重要作用,不恰当的T细胞免疫应答会导致相关免疫疾病的发生。因此,T细胞活化必须受到严格精细的调控。T细胞活化,起始于T细胞受体(T cell receptor,TCR)复合物特异性地识别抗原递呈细胞APC所递呈的MHC抗原肽复合物pMHC,接着转化为TCR信号及其 T lymphocytes are the core components of the body’s adaptive immune system. The immune response mediated by T lymphocytes plays an important role in the clearance of invading pathogens or diseased cells. Inappropriate T-cell immune responses can lead to immune-related diseases occur. Therefore, T cell activation must be strictly and finely regulated. T cell activation, starting from the T cell receptor (TCR) complex specifically recognizing the MHC antigen peptide complex pMHC presented by the APC of the antigen presenting cell, followed by conversion to the TCR signal and its