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多巴胺在脑缺血再灌注损伤中起重要作用,缺血再灌注时多巴胺释放明显增加,过量释放的多巴胺可以直接或 间接对神经细胞产生毒性作用。多巴胺的神经毒性作用机制尚未完全阐明,主要观点为:①多巴胺自身的神经毒性;②多巴胺 代谢产物的神经毒性;③增强兴奋性氨基酸的毒性;④诱导凋亡。
Dopamine plays an important role in cerebral ischemia-reperfusion injury. Dopamine release is significantly increased after ischemia-reperfusion. The excessive release of dopamine can directly or indirectly produce toxic effects on nerve cells. The mechanism of dopamine neurotoxicity has not yet been fully elucidated, the main points of view: ① dopamine neurotoxicity; ② dopamine metabolites neurotoxicity; ③ enhance the excitotoxicity of amino acids; ④ induce apoptosis.