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[目的]探讨汕头地区近15年青年结直肠癌的临床特点及预后情况。[方法]回顾汕头地区两家医院1993～2008年间收治的672例青年(≤40岁)结直肠癌资料。[结果]近15年青年结直肠癌收治率增加82.80%,但构成比却下降2.48%(P=0.03);发病中位年龄上升5岁;早期诊断率(≤3个月)提高11.09%,误诊率下降12.35%(P<0.05);结直肠癌中直肠癌比例从55.78%下降至45.32%(P<0.05);根治性手术及辅助放、化疗比例明显提高(P<0.05),Ⅲ期患者5年生存率显著提高(P<0.05);而男女比例、病理类型、TNM分期、结直肠癌肿右半结肠癌比例及3、5年总生存率差异无统计学意义(P>0.05)。[结论]近15年汕头地区青年结直肠癌的发病比例下降,发病年龄上升,直肠癌比例下降,早期诊断率上升,误诊率下降,Ⅲ期患者5年生存率显著提高,但总生存率并未明显提高。
[Objective] To investigate the clinical features and prognosis of colorectal cancer in Shantou in recent 15 years. [Methods] The data of 672 young patients (≤40 years) with colorectal cancer admitted to the two hospitals in Shantou from 1993 to 2008 were retrospectively reviewed. [Results] The incidence of colorectal cancer in the past 15 years increased by 82.80%, but the constituent ratio decreased by 2.48% (P = 0.03); the median age of the patients increased by 5 years; the early diagnosis rate (≤3 months) increased by 11.09% The misdiagnosis rate decreased by 12.35% (P <0.05); the proportion of rectal cancer in colorectal cancer decreased from 55.78% to 45.32% (P <0.05); the proportion of radical operation and adjuvant radiotherapy and chemotherapy was significantly increased (P <0.05) The 5-year survival rate was significantly increased (P <0.05). There was no significant difference in the proportions of men and women, pathological types, TNM staging, the proportion of right colon cancer with colorectal cancer and the overall 3 and 5 year survival rates (P> 0.05) . [Conclusion] The incidence of colorectal cancer in Shantou area decreased in recent 15 years. The age of onset was increased, the proportion of rectal cancer was decreased, the early diagnosis rate was increased, the misdiagnosis rate was decreased, and the 5-year survival rate of stage Ⅲ patients was significantly increased. However, the overall survival rate Not significantly improved.