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作者采用放免法测定了６９例慢性乙型肝炎患者活动期和静止期血清ＴＳＨ、Ｔ３、Ｔ４、γＴ３和Ｔ３Ｕ水平。结果发现慢性迁延性肝炎活动期ＴＳＨ、Ｔ３明显低于正常人（Ｐ＜０．０１），静止期恢复正常；慢性活动性肝炎和肝炎后肝硬化ＴＳＨ、Ｔ３、Ｔ４和Ｔ３ｕ均显著下降（Ｐ＜０．０１），静止期Ｔ３显著回升（Ｐ＜０．０１），Ｔ３Ｕ亦有回升，以慢性活动性肝炎更明显。结果表明，慢性肝病患者垂体─甲状腺轴分泌功能有异常，Ｔ３的降低与回升幅度可直接反映肝脏病变的严重程度与恢复状态。
The authors measured the levels of serum TSH, T3, T4, γT3 and T3U in 69 patients with chronic hepatitis B during active and quiescent periods by radioimmunoassay. The results showed that the activities of TSH, T3 in patients with chronic persistent hepatitis were significantly lower than those in normal controls (P <0.01), and the quiescence returned to normal. The levels of TSH, T3, T4 and T3u in chronic active hepatitis and posthepatitis cirrhosis were significantly decreased <0.01). The quiescent T3 increased significantly (P <0.01), T3U also increased, and chronic active hepatitis was more obvious. The results showed that patients with chronic liver disease have abnormal secretion of pituitary-thyroid axis, and the decrease and recovery of T3 can directly reflect the severity and recovery status of liver disease.