文章以香港牡蛎 (Crassostrea hongkongensis) 酶解产物为研究对象，采用大鼠超负荷哺乳模型，通过测定母鼠泌乳量、仔鼠总平均体质量增加量、母鼠脏器指数、母鼠乳腺器官指数和血清催乳素 (Prolactin, PRL) 等指标，使用HE染色法观察母鼠乳腺组织结构，探讨牡蛎酶解产物 (Oyster enzymatic hydrolysate products, OEHP) 对产后超负荷哺乳母鼠泌乳的影响。结果显示，灌胃21 d中，相较于对照组，OEHP高剂量组母鼠每小时泌乳量显著增加，低剂量组的效果不显著，与剂量呈正相关。高剂量组母鼠总平均泌乳量增加57.85%，差异极显著 (P<0.01)；中剂量组增加38.02%，差异显著 (P<0.05)；低剂量组增加17.69%；高、中、低剂量组仔鼠体增重分别增加13.62%、12.28%、11.99%，差异极显著 (P<0.01)，且高剂量组与中、低剂量组间仔鼠体增重有显著差异 (P<0.05)；乳腺指数均有显著差异；脏器指数均有不同程度的增加；高剂量组PRL浓度增加41.67%，差异极显著 (P<0.01)；中剂量组增加26.39%，差异显著 (P<0.05)；低剂量组增加11.11%；与低剂量组相比，高剂量组的PRL浓度增加27.50%，差异显著 (P<0.05)；观察发现各组母鼠乳腺组织结构均有明显的扩大和充盈现象，说明OEHP能有效改善超负荷哺乳母鼠泌乳调节作用从而促进泌乳。“,”Taking the enzymatic hydrolysate of Crassostrea hongkongensis as subjects, we used overloaded lactation model to investigate the effects of oyster enzymatic hydrolysate products (OEHP) on lactation of overloaded lactating rats by measuring the lactation volume of female rats, total average body mass increment of offspring, organ index of female rats, mammary gland organ index of female rats and serum prolactin (PRL). The mammary gland structure was observed by HE staining method. The results show that within 21 d of gavage, compared with control group, the increase of hourly lactation was significant in high-dose group, but not significant in low-dose group, positively correlated with the dose. The total average lactation of high-dose group increased by 57.85% (P<0.01); for low- and medium-dose groups, the lactation growth was 38.02% (P<0.05) and 17.69%, respectively. The body weight gain of young mice in high-, medium- and low-dose groups increased by 13.62%, 12.28% and 11.99%, respectively (P<0.01). There was significant difference in the body weight gain between high-dose group and medium-, low-dose groups (P<0.05). The mammary gland index had significant difference. The organ index increased to varying degrees. The PRL concentration in high-, medium- and low-dose groups increased by 41.67% (P<0.01), 26.39% (P<0.05) and 11.11%, respectively. Compared with low-dose group, the PRL concentration in high-dose group increased by 27.50% (P<0.05). In addition, the mammary gland structure of female rats in each group had been obviously enlarged and filled, which indicates that OEHP can improve the regulation of lactation within overloaded lactating rats effectively and promote lactation.