The impact process between car driver’s head and seat head restraint during a car rear end collision is simulated, where the multiphase and nonlinear features of the human brain tissues and the foam material of the seat head restraint are considered. Using the FEM-software LS-DYNA, the brain tissue deformation caused by a car REC is calculated. The purpose of this work is to supply references for improving the design of the head protective devices. The results show that the maximum shear strain appears near the boundaries of different phases and there is a great shear strain gradient in the brain tissues.