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本文报道了用传统流感病毒灭活疫苗经非肠道途径免疫不同年龄组人群后细胞毒性T淋巴细胞(CTL)记忆及血清和局部抗体应答。 作者将47名健康成人分成3组,青年组(年龄≤40岁)15人,中年组(40～64岁)15人,老年组(65岁以上)17人,肌肉注射0.5ml的3价亚单位流感疫苗,于免疫后0、2和12周分别收集全血、血清和鼻灌洗液,并从老年组收集免疫后14～16周的全血标本。检测流感病毒特异性CTL活性、血清和鼻灌洗液中血凝素(HA)特异性抗体滴度。
This article reports the memory and serum and local antibody responses of cytotoxic T lymphocytes (CTLs) after immunization of poultry with different age groups by a parenteral route using a conventional influenza virus inactivated vaccine. Forty-seven healthy adults were divided into three groups: 15 in the youth group (≤40 years of age), 15 in the middle-aged group (40 to 64 years) and 17 in the elderly group (65 and over) Subunit influenza vaccine, whole blood, serum and nasal lavage fluid were collected at 0, 2 and 12 weeks after immunization, and whole blood samples were collected from the aged group 14 to 16 weeks after immunization. The influenza virus specific CTL activity, hemagglutinin (HA) specific antibody titers in serum and nasal lavage fluid were measured.