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福寿草(Adonis amurensis Regel et Radde)具有类似洋地黄的强心作用,对大脑皮层及呼吸中枢尚有抑制作用。近年来报导,该药确有镇静作用,且对某些心脏病患者有一定意义。此外,文献记载,中毒剂量的福寿草可致呕吐、恶心、多汗、腹痛、头痛眩晕、视物不清、心悸等中毒症状,这些作用是否与中枢神经系统有关,则尚未见报导。本文以家兔大脑皮层电活动、行为变化、颈肌肌电、心电和脑内5-羟色胺含量等为指标,初步研究国产福寿草总甙的镇静及毒性作用的原理。
Adonis amurensis Regel et Radde has a cardiotonic effect similar to digitalis, and it has inhibitory effects on the cerebral cortex and respiratory center. In recent years, the drug has indeed had a sedative effect and it has certain significance for certain heart patients. In addition, the literature records that toxic doses of Fuhou grass can cause vomiting, nausea, sweating, abdominal pain, headache, dizziness, blurred vision, heart palpitations and other symptoms of poisoning, whether these effects are related to the central nervous system, it has not yet been reported. In this paper, the principle of the sedative and toxic effects of the domestic carp (Blossoms mellifera) was primarily studied using the electrical activity, behavioral changes, cervical myoelectricity, electrocardiogram, and brain 5-hydroxytryptamine content.