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目的探讨血清抗苗勒管激素水平(AMH)及年龄在体外受精-胚胎移植(IVF-ET)或卵母细胞浆内单精子显微注射(ICSI)治疗过程和结局的作用。方法将169例首次应用Gn RH-a短效制剂长方案促排卵行IVF-ET或ICSI的患者,根据妊娠结局分为妊娠组(n=97)和非妊娠组(n=72),比较两组患者的一般特点,月经第2/3天血清基础内分泌激素水平及AMH水平,获卵数,受精率等促排卵相关参数,并进行分析。结果在妊娠和非妊娠组中,患者体重指数(BMI),不孕年限,月经第2/3天血清基础内分泌激素水平及AMH水平,HCG日激素水平,HCG日子宫内膜厚度均无统计学差异(P>0.05);年龄,促排卵时间,促排卵使用促性腺激素(Gn)天数及Gn总量、获卵数、受精率及冷冻胚胎数均有统计学差异(P<0.05)。结论血清AMH水平与IVF-ET助孕的临床结局无直接相关性,而年龄才是预测卵子质量的独立指标,与最后的临床妊娠结局密切相关。
Objective To investigate the effects of serum anti-Mullerian hormone (AMH) and age on IVF-ET or intracytoplasmic sperm injection (ICSI) in oocytes. Methods One hundred and sixty-nine patients with IVF-ET or ICSI who had been given ovulation induction for a long term with GnRH-a short-acting formulation were divided into pregnancy group (n = 97) and non-pregnancy group (n = 72) The general characteristics of patients, menstrual 2/3 days serum basal endocrine hormone levels and AMH levels, number of oocytes, fertilization rate and other ovulation-related parameters, and analyzed. Results In pregnancy and non-pregnancy group, there were no significant differences in body mass index (BMI), duration of infertility, serum basal endocrine hormone level and AMH level, HCG-day hormone level and HCG endometrial thickness on the 2nd / 3rd day of menstruation (P> 0.05). There were significant differences in age, ovulation induction time, the number of gonadotrophin (Gn) days and Gn in ovulation induction, the number of oocytes retrieved, the fertilization rate and the number of frozen embryos (P <0.05). Conclusion There is no direct correlation between serum AMH level and clinical outcome of IVF-ET pregnancy. Age is an independent index to predict egg quality, which is closely related to the final clinical pregnancy outcome.