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[目的]探讨阿奇霉素联合头孢曲松治疗社区获得性肺炎(CAP)的疗效及其它影响。[方法]300例CAP患者随机分成AC组和CE组各150例,每组中伴有肺炎衣原体(Cpn)感染16例。AC组给予阿齐霉素和头孢曲松钠治疗,CE给予头孢曲松钠治疗。用微量免疫荧光法检测抗Cpn抗体效价,胶体金法(DIGFA)快速定量测定C-反应蛋白(CRP)。[结果]治疗后AC组Cpn-IgM抗体滴度下降(P<0.05)、Cpn-IgM阳性率下降(P=0.051);两组CRP均下降;AC与CE组总有效率类似(分别为98.0%和95.3%);细菌总清除率也类似(分别为88.1%和86.8%)。[结论]AC与CE组治疗CAP都有良好疗效,阿奇霉素对伴有Cpn急性感染者疗效较好。
[Objective] To investigate the efficacy and other effects of azithromycin combined with ceftriaxone on community-acquired pneumonia (CAP). [Methods] 300 patients with CAP were randomly divided into AC group and CE group, 150 cases each with 16 cases of Cpn infection. AC was given azithromycin and ceftriaxone sodium treatment, CE ceftriaxone sodium treatment. Anti-Cpn antibody titers were detected by micro-immunofluorescence and C-reactive protein (CRP) was rapidly quantified by colloidal gold assay (DIGFA). [Results] The titer of Cpn-IgM antibody in AC group was decreased (P <0.05) and the positive rate of Cpn-IgM was decreased in AC group (P = 0.051). The CRP of both groups were decreased. The total effective rates of AC and CE group were 98.0 % And 95.3% respectively). The total bacterial clearance rate was also similar (88.1% and 86.8% respectively). [Conclusion] Both AC and CE group have good curative effect on CAP, azithromycin has a good curative effect on acute infection with Cpn.