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由于某些抗疟药物在临床上可用于治疗胶原性疾病,近年来,在国内的矽肺实验治疗科研工作中,已对这类药物进行了筛选,抗矽-14号就是其中之一。抗矽-14号学名为1,3-双[4-(7-氯代喹啉基-4)哌哔嗪-1]丙烷磷酸盐,简称磷酸喹哌,是一种长效的抗疟药。在动物实验治疗有效的基础上,去年已开始将抗矽-14号试用于矽肺临床治疗。现将我们于1974年8月至1975年1月试用半年的10例单纯矽肺病例的治疗情况小结如下。
Some anti-malarial drugs are clinically useful in the treatment of collagen diseases. In recent years, anti-silico-14 drugs have been screened in silico experimental treatment research in China. Silicon anti-Si-14 is called 1,3-bis [4- (7-chloroquinolyl-4) piperazine-1] propane phosphate, referred to as Quipiper phosphate is a long-term antimalarial medicine. On the basis of the effective treatment of animal experiments, last year has started anti-Si-14 trial for clinical treatment of silicosis. Now we from August 1974 to January 1975 trial of six months of simple treatment of silicosis cases are summarized below.