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早在40年代即有人提出,从正常激素靶组织起源的癌有激素依赖和不依赖之分。这一概念的发展导致了针对肿瘤对激素应答这一特点而设计的治疗方法的问世。用操纵激素的方法治疗激素依赖的乳房癌和前列腺癌已有数十年历史,并获得一定疗效。胃肠道粘膜和胰腺等是胃肠激素的靶组织。一些胃肠激素可刺激正常胃肠道粘膜和胰腺细胞生长,这些激素可能也具有促进部分胃肠道和胰腺癌肿生长的作用。因此亦有可能用操纵
As early as in the 1940s, it was suggested that cancers that originate from normal hormonal target tissues have hormone-dependent and independent-dependence. The development of this concept led to the advent of therapeutic methods designed for the hormonal response of tumors. Hormone-dependent treatment of hormone-dependent breast and prostate cancers has been used for decades and has achieved certain results. Gastrointestinal mucosa and pancreas are the target tissues of gastrointestinal hormones. Some gut hormones stimulate the growth of normal gastrointestinal mucosa and pancreatic cells, and these hormones may also have a role in promoting the growth of some gastrointestinal and pancreatic cancers. So it is also possible to use manipulation