Purpose: To compare the survival rates of patients with exfoliative glaucoma ( XFG) and those with primary open-angle glaucoma (POAG), and to establish whethe r the use of acetazolamide has any influence on survival. Methods: The survival data, including date and cause of death, for 1147 patients with XFG or POAG who were ultimately hospitalized at the Eye Department, National Hospital, Oslo, bet ween 1961 and 1970, were analysed retrospectively. The Cox proportional hazard m odel was used in the survival analyses. Results: No statistically significant di fferences in survival were found between patients with XFG and those with POAG ( P=0.85). As expected, female gender and younger age at diagnosis were associated with longer survival periods. Surprisingly, we found that patients with more re cent birth dates had relatively lower survival rates than patients with earlier birth dates; when this was included in the analyses, the use of acetazolamide wa s found to be associated with reduced survival (n=492, P=0.02). Purpose: To compare the survival rates of patients with exfoliative glaucoma (XFG) and those with primary open-angle glaucoma (POAG), and to establish whethe r use of acetazolamide has any influence on survival. Methods: The survival data, including date and cause of death, for 1147 patients with XFG or POAG who were ultimately hospitalized at the Eye Department, National Hospital, Oslo, bet ween 1961 and 1970, were was analyzed retrospectively. The Cox proportional hazard m odel was used in the survival analyzes. : No pure significant f ff in survival were found between patients with XFG and those with POAG (P = 0.85). As expected, female gender and younger age at diagnosis were associated with longer survival periods. Surprisingly, we found that patients with more re cent birth dates had relatively lower survival rates than patients with earlier birth dates; when this was included in the analyzes, the use of acetazolamide wa found found be associated with reduc ed survival (n = 492, P = 0.02).