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成人急性淋巴细胞白血病(acute lymphocyticleukemia,ALL)的治疗效果远较小儿差。作者设计一种可改善成人 ALL 预后的治疗方案。1980年10月～1986年3月,收治成人 ALL81例,患者年龄均不到50岁,先前没有接受过化疗,或只接受过短于2周的长春新碱及强的松治疗。方法化疗分3个阶段进行:①诱导缓解:柔红霉素50mg/M~2静注第1～3天,长春新碱2mg 静注第1、8、15、22天,强的松60mg/M~2口服第1～28天,左旋门冬酰胺酶6000U/M~2肌注第17～28天。如果化疗第14天骨髓未缓解,第15天用柔红霉素50mg/M~2静注。如果第28天骨髓仍未缓解,给予柔红霉素
Adult acute lymphoblastic leukemia (ALL) treatment of children is far worse. The authors designed a treatment that would improve the prognosis of adults with ALL. From October 1980 to March 1986, ALL81 patients were enrolled in this study. All patients were under 50 years of age. They had not received chemotherapy before or had received vincristine and prednisone for less than 2 weeks. Methods Chemotherapy was divided into three stages: ① induction of remission: daunorubicin 50mg / M ~ 2 intravenous 1 to 3 days, 2mg intravenous vincristine 1,8,15,22 days, prednisone 60mg / M ~ 2 oral 1 to 28 days, L-asparaginase 6000U / M ~ 2 intramuscular injection of 17 to 28 days. If the bone marrow was not relieved on the 14th day of chemotherapy, intravenously injected daunorubicin 50mg / M ~ 2 on the 15th day. Daunorubicin is given if the bone marrow remains untreated on the 28th day