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作者曾报道在正常妇女黄体期中期,给予鼻内注入一种LHRH的高活性类似物——Buserelin(HOE-766,D-丝〔丁叔〕~6-去甘~(10)-LHRH乙基酰胺),或单次用1,000μg或连用两次500μg,可使孕酮及雌二醇水平降低,黄体期缩短1～4天。若在黄体期第六至九天用药,该类似物的溶黄体作用最强。本文观察了在正常妇女的中期LH峰以后每天(第一至十天)注射该类似物对于促性腺激素分泌和黄体机能的影响。选33例19～40岁的正常妇女为志愿者。月经周期规律,无内分泌及妇科疾患。在开始试验前至少6个月未用口服避孕药及激素制剂。整个研究包括
The authors reported that intranasal injection of a highly active analogue of LHRH - buserelin (HOE-766, D- Amide), or with a single use of 1,000μg or twice in combination with 500μg, progesterone and estradiol levels can be reduced luteal phase shortened 1 to 4 days. If the luteal phase from the sixth to nine days of medication, the role of the most effective levonitine analog. This article examines the effect of injecting this analogue on gonadotropin secretion and corpus luteum function daily (days 1 to 10) after normal-term LH peaks in normal women. 33 normal women aged 19 to 40 were selected as volunteers. Menstrual cycle rules, no endocrine and gynecological disorders. Oral contraceptives and hormonal preparations were not used for at least 6 months before starting the test. The entire study included