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目的 评价卵巢移行细胞癌 (TCC)的临床生物学行为、预后以及影响预后的因素。方法 回顾性分析北京协和医院妇产科 2 0年间收治的卵巢TCC 5 8例的临床资料 ,并进行统计学分析。结果 5 8例患者中 ,年龄中位数为 3 5～ 75岁 ,平均为 (5 5± 10 )岁。 40例为单侧 (69% ) ,CA12 5水平为 75～ 143 3U/L ,平均为 (687± 3 65 )U/L。 5 8例患者均在我院接受肿瘤细胞减灭术 ,40例 (69% )患者达到满意的肿瘤细胞减灭术效果 ,病理分级为G1、G2 、G3级者分别为 7% (4/ 5 8)、45 % (2 6/ 5 8)和 48%(2 8/ 5 8)。 5 8例中 ,2 3例 (40 % )有淋巴结转移 ;46例 (79% )手术病理分期为Ⅲ期和Ⅳ期。所有患者均接受了不同疗程的化学药物治疗 ,2 6例 (45 % )术后复发 ,3 1例 (5 3 % )死亡。对于可能影响预后的各因素进行分析发现 ,本病的预后与手术彻底性 (P <0 0 1)、术前CA12 5水平 (P <0 0 1)、双侧卵巢受累(P <0 0 5 )以及淋巴结转移 (P <0 0 5 )有良好的相关性。结论 卵巢TCC的临床生物学行为较好
Objective To evaluate the clinical biological behavior, prognosis and prognosis of ovarian transitional cell carcinoma (TCC). Methods The clinical data of 8 cases of ovarian TCC admitted in the obstetrics and gynecology department of Peking Union Medical College Hospital during 20 years were retrospectively analyzed and statistically analyzed. Results Among the 58 patients, the median age ranged from 35 to 75 years, with an average of (55 ± 10) years. 40 cases were unilateral (69%), CA12 5 levels were 75 ~ 143 3U / L, with an average of (687 ± 3 65) U / L. Fifty-eight patients underwent tumor cytoreductive surgery in our hospital. Satisfactory cytoreductive efficacy was achieved in 40 patients (69%). The pathological grade was G1, G2, and G3, respectively 8), 45% (26/58) and 48% (28/58). Of the 58 cases, 23 (40%) had lymph node metastases; 46 (79%) had pathological stages of stage Ⅲ and Ⅳ. All patients received different courses of chemotherapy, 26 (45%) relapsed and 31 (53%) died. The prognosis of the factors that may affect the prognosis of the disease and surgical thoroughness (P <0 01), preoperative CA12 5 levels (P lt; 0 01), bilateral ovarian involvement (P lt; 05 ) And lymph node metastasis (P <0 05). Conclusion The clinical biological behavior of ovarian TCC is better