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本研究探讨异基因造血干细胞移植(allo-HSCT)后急性肾衰竭(acute renal failure,ARF)的发生率、危险因素以及对患者预后的影响。采用回顾性研究方法,对86例allo-HSCT患者的资料进行了分析。采用单因素分析及多因素Logistic回归模型分析,研究了ARF发生的危险因素。使用Cox回归法分析了ARF与allo-HSCT患者生存时间的关系。结果表明:ARF发生率为31.40%,发病中位时间为allo-HSCT后59.5天。单因素及多因素分析发现,移植前肾脏疾病、败血症或感染中毒性休克、高胆红素血症为allo-HSCT后ARF发生的独立危险因素。同时,ARF是影响allo-HSCT患者生存的独立危险因素。结论:Allo-HSCT后ARF发生率高;败血症或感染中毒性休克、高胆红素血症、既往肾脏病史是allo-HSCT后ARF发生的独立危险因素;ARF是影响allo-HSCT患者生存时间的独立危险因素。
This study was to investigate the incidence of acute renal failure (ARF) after allogeneic hematopoietic stem cell transplantation (allo-HSCT), the risk factors and the prognosis of patients. The data of 86 patients with allo-HSCT were analyzed retrospectively. Univariate analysis and multivariate logistic regression analysis were used to analyze the risk factors of ARF. The relationship between ARF and survival time in allo-HSCT patients was analyzed using Cox regression. The results showed that the incidence of ARF was 31.40% and the median time to onset was 59.5 days after allo-HSCT. Univariate and multivariate analysis showed that prerenal kidney disease, sepsis or toxic shock and hyperbilirubinemia were independent risk factors of ARF after allo-HSCT. At the same time, ARF is an independent risk factor for the survival of allo-HSCT patients. Conclusion: The incidence of ARF after Allo-HSCT is high. Sepsis or toxic shock, hyperbilirubinemia and previous renal disease are independent risk factors of ARF after allo-HSCT. ARF is the effect of allo-HSCT on survival time Independent risk factors.