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目的 :探讨原癌基因真核细胞翻译起始因子 (eIF4E)在喉鳞癌中的表达及其与临床病理特征的相关性。方法 :选取 37例经病理证实为喉鳞癌的石蜡标本和 10例病理证实为声带息肉的石蜡标本 ,用抗eIF4E多克隆抗体为标记物 ,采用免疫组织化学SP法检测组织细胞中eIF4E抗原的表达。结果 :37例喉鳞癌石蜡标本中eIF4E表达均阳性 ,而声带息肉标本中eIF4E表达均阴性。eIF4E与患者年龄、性别、肿瘤发生部位无关 (P >0 .0 5 )。eIF4E积分与TNM分期、病理分级相关 (P <0 .0 1) ,且eIF4E积分随分期、分级呈递增性增高。T、N分期各组与病理分级各组之间eIF4E积分差异有显著性意义 (P <0 .0 1)。术后复发转移组eIF4E积分远高于无复发转移组 (P <0 .0 1)。结论 :eIF4E在喉鳞癌的发生、发展、浸润、转移中起重要作用 ,eIF4E的表达与喉鳞癌TNM分期、病理分级、复发转移相关 ,可望作为喉鳞癌的肿瘤敏感的分子指标和预后标志
Objective: To investigate the expression of eIF4E, a proto-oncogene in laryngeal squamous cell carcinoma and its correlation with clinicopathological features. Methods: Seventy-seven paraffin-embedded specimens confirmed by pathology as laryngeal squamous cell carcinoma and 10 paraffin-embedded specimens confirmed by pathology as vocal cord polyps were collected. Anti-eIF4E polyclonal antibody was used as marker and immunohistochemical SP method was used to detect the expression of eIF4E antigen expression. Results: The expression of eIF4E was positive in paraffin - embedded specimens of 37 cases of laryngeal squamous cell carcinoma, while the expression of eIF4E in vocal cord polyps was negative. eIF4E was not related to patient’s age, sex, tumor location (P> 0.05). The score of eIF4E was correlated with TNM stage and pathological grade (P <0.01), and the score of eIF4E increased progressively with the stage. There was significant difference in eIF4E score between T, N stages and pathological grading groups (P <0.01). The postoperative recurrence and metastasis eIF4E score was much higher than the no recurrence and metastasis (P <0.01). Conclusions: eIF4E plays an important role in the occurrence, development, invasion and metastasis of laryngeal squamous cell carcinoma. The expression of eIF4E correlates with the TNM stage, pathological grade, recurrence and metastasis of laryngeal squamous cell carcinoma and is expected to serve as a sensitive molecular marker of laryngeal squamous cell carcinoma Prognosis sign