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运用化疗荷瘤小鼠模型，测胸腺和脾指数，３ＨＴｄＲ掺入法测胸腺细胞增殖，中性红比色法测腹腔巨噬细胞吞噬功能，计算抑瘤率。结果：黄芪Ｓ４加环磷酰胺组与环磷酰胺组比较，胸腺、脾指数、腹腔巨噬细胞吞噬功能、胸腺细胞增殖均有显著差别。单用黄芪Ｓ４亦能促进荷瘤小鼠胸腺细胞增殖，并对Ｓ１８０实体瘤有抑制作用，抑瘤率为３５７８％。研究表明黄芪Ｓ４与化疗药合用能改善化疗造成的免疫抑制，且有抑瘤作用
The thymocyte and spleen index were measured in the tumor-bearing mice model by chemotherapy, and the proliferation of thymocytes was measured by 3H-TdR incorporation method. The phagocytic function of macrophages was measured by neutral red colorimetric method and the tumor inhibition rate was calculated. RESULTS: Compared with the cyclophosphamide group, the Astragalus S4 plus cyclophosphamide group had significant differences in thymus, spleen index, phagocytosis of peritoneal macrophages, and proliferation of thymocytes. Single use of Astragalus S4 can also promote the proliferation of tumor-bearing mice with thymocytes, and inhibit S180 solid tumors, the inhibition rate of 35.78%. Studies have shown that Astragalus S4 combined with chemotherapeutic drugs can improve immunosuppression caused by chemotherapy and have anti-tumor effect