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目的 探讨口腔鳞癌对口腔黏膜菌群的影响。方法 分别检测42例口腔鳞癌患者病变区黏膜、对侧正常黏膜所培养细菌的数量、构成比和检出率。结果 病变区黏膜每平方厘米细菌量(x=5.21×10~5 CFU/cm~2,lgx=5.7169)远高于对侧正常黏膜,优势菌群发生改变,病变区黏膜有外籍菌定植(白色念珠菌、绿脓杆菌)。结论 口腔鳞癌可导致患者口腔菌群失调,增加感染的危险性,易继发局部或全身感染。
Objective To investigate the effect of oral squamous cell carcinoma on oral mucosal flora. Methods 42 cases of oral squamous cell carcinoma in the diseased area mucosa, contralateral normal mucosa cultured bacteria number, composition ratio and detection rate. Results The number of bacteria per square centimeter of the mucosa in the diseased area was much higher than that of the normal mucosa (x = 5.21 × 10 ~ 5 CFU / cm ~ 2, lgx = 5.7169) Candida, Pseudomonas aeruginosa). Conclusion Oral squamous cell carcinoma can cause oral flora imbalance in patients with increased risk of infection, secondary or systemic infection.