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目的研究功能性消化不良(FD)患者症状与其心理、生活事件以及生活质量方面的关联性。方法选择从2012年12月至2015年11月在医院消化内科就诊的FD患者100例纳入观察组,另选同期在医院进行体检的健康志愿受试者100例纳入对照组,测评分析两组对象焦虑及抑郁、生活事件以及生活质量评分与症状的关系。结果 FD组症状分、SAS、SDS评分以及焦虑、抑郁的发生率均明显高于对照组,差异有统计学意义(P<0.05),且患者的FD症状与SAS及SDS均呈正相关(r=0.649,0.723;P=0.000,0.000)。FD组的生活事件中正性事件分值明显低于对照组,而负性事件及生活事件总值明显高于对照组,差异均有统计学意义(P<0.05)。但患者的FD症状与正性事件、负性事件以及生活事件总值均无明显的相关性(r=-0.236,0.125,0.221;P=0.134,0.217,0.148)。FD组患者8个健康概念上的生活质量评分均分别明显低于对照组,差异有统计学意义(P<0.05)。患者的FD症状与生理功能(r=-0.633,P=0.001)、生理职能(r=-0.783,P=0.000)、情感职能(r=-0.649,P=0.000)、精神健康(r=-0.751,P=0.000)、社会功能(r=-0.686,P=0.000)以及总体健康(r=-0.742,P=0.000)均具有明显的负相关。结论功能性消化不良的发生与患者的焦虑抑郁状态以及生活质量具有紧密相关性,值得临床重视。
Objective To investigate the association between symptoms and psychology, life events and quality of life in patients with functional dyspepsia (FD). Methods From December 2012 to November 2015, 100 FD patients admitted to the hospital for digestive medicine were enrolled in the observation group and 100 healthy volunteers who were selected for physical examination in the hospital during the same period were enrolled in the control group. The two groups of patients Anxiety and depression, life events and quality of life scores and symptoms. Results The scores of symptom scores, SAS, SDS scores and the incidence of anxiety and depression in FD group were significantly higher than those in control group (P <0.05), and the FD symptoms were positively correlated with SAS and SDS (r = 0.649, 0.723; P = 0.000, 0.000). The scores of positive events in life events in FD group were significantly lower than those in control group, but the values of negative events and life events in control group were significantly higher than those in control group (P <0.05). However, patients with FD symptoms and positive events, negative events and the total number of life events were not significantly correlated (r = -0.236,0.125,0.221; P = 0.134,0.217,0.148). The quality of life scores of 8 healthy individuals in the FD group were significantly lower than those in the control group respectively, with significant difference (P <0.05). The patients with FD symptoms and physical function (r = -0.633, P = 0.001), physical function (r = -0.783, P = 0.000) 0.751, P = 0.000), social function (r = -0.686, P = 0.000) and overall health (r = -0.742, P = 0.000). Conclusion The occurrence of functional dyspepsia is closely related to the patients’ anxiety and depression status and quality of life, which deserves clinical attention.