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目的探求血清8-异构前列腺素F2α(8-iso-PGF2α)检测对临床冠心病的意义。方法56例冠心病患者,其中包括急性心肌梗死(AMI组)18例、不稳定型心绞痛(UAP组)23例、稳定型心绞痛(SAP组)15例,设正常对照20例,采用ELISA法检测四组血清中8-iso-PGF2α浓度,分析和比较各组血清8-iso-PGF2α浓度。结果冠心病三个亚组,AMI组、UAP组、SAP组和正常对照组的8-iso-PGF2α水平分别为(537.33±53.24)ng/ml、(276.68±30.61)ng/ml、(191.94±21.12)ng/ml、(66.22±13.29)ng/ml,冠心病三个亚组与正常对照组之间的差异均有统计学意义(P<0.01),AMI组与其他组差异有统计学意义(P<0.0001),且8-iso-PGF2α随冠心病严重程度递增,两者之间呈直线相关(r=0.766,P<0.001,直线回归方程为y=-120.416+153.586x),但UAP组和SAP组的差异无统计学意义(P=0.072)。结论冠脉病变越严重,血清8-iso-PGF2α水平越高,提示冠状动脉血管急性闭塞时有严重的脂质氧化应激损伤,而且临床冠心病的严重程度与氧化应激性损伤的严重程度正相关。
Objective To investigate the significance of serum 8-iso-prostaglandin F2α (8-iso-PGF2α) in clinical coronary heart disease. Methods Fifty-six patients with coronary heart disease, including 18 patients with acute myocardial infarction (AMI), 23 patients with unstable angina (UAP), 15 patients with stable angina (SAP) and 20 normal controls were enrolled in this study. Four groups of serum 8-iso-PGF2α concentration, analysis and comparison of serum 8-iso-PGF2α concentration. Results The levels of 8-iso-PGF2α in AMI group, UAP group, SAP group and normal control group were (537.33 ± 53.24) ng / ml, (276.68 ± 30.61) ng / ml, 21.12) ng / ml, (66.22 ± 13.29) ng / ml respectively. There was significant difference between the three subgroups of CHD and the normal control group (P <0.01). The difference between AMI group and other groups was statistically significant (P <0.0001), and the 8-iso-PGF2αincreased with the severity of coronary heart disease. There was a linear correlation between them (r = 0.766, P <0.001, linear regression equation was y = -120.416 + 153.586x) There was no significant difference between the SAP group and the SAP group (P = 0.072). Conclusions The more serious the coronary artery disease is, the higher the level of serum 8-iso-PGF2α is, suggesting that there is serious lipid oxidative stress injury in the acute coronary artery occlusion. Moreover, the severity of clinical coronary heart disease and the severity of oxidative stress injury Positive correlation.