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[目的]了解小儿败血症患者病原菌感染谱及耐药性的变化。[方法]对2004年1月至2005年12月本院儿科2 260例住院儿童血培养结果进行分析和总结。[结果]2260例血培养共检出细菌339株,检出率15.0%,其中凝固酶阴性葡萄球菌最多(63.4%);药敏试验结果表明,大部分革兰阳性球菌对青霉素和头孢类等常用药物耐药。[结论]葡萄球菌是引起小儿败血症的主要病原菌,对常用的抗菌药物耐药比例较高,应引起临床的高度重视。
[Objective] To understand the changes of pathogen infection spectrum and drug resistance in pediatric sepsis patients. [Methods] The blood culture results of 2 260 hospitalized children in pediatrics of our hospital from January 2004 to December 2005 were analyzed and summarized. [Results] A total of 339 bacteria were detected in 2260 blood cultures, the detection rate was 15.0%, of which coagulase-negative staphylococci were the most (63.4%). The results of drug sensitivity test showed that most of the Gram-positive cocci were resistant to penicillin and cephalosporin Common drug resistance. [Conclusion] Staphylococcus aureus is the main causative agent of pediatric sepsis and its resistance to commonly used antimicrobial agents is high, which should arouse great attention in clinic.