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伴微量白蛋白尿的2型糖尿病患者(DM-MA)36例,不伴微量白蛋白尿的(DM-NA)29例,正常对照组(NC)20例。3组患者均行空腹血糖、胰岛素、血脂等测定,并计算HOMA-IR评估组织胰岛素抵抗,根据结果进行比较分析,将所有患者的尿白蛋白排泄率(UAER)与有关因素进行多元回归分析。结果:DM-MA组与DM-NA组HOMA-IR均高于NC组,差异非常显著(P<0.01),DM-MA组HOMA-IR示明显高于DM-NA组(P<0.05),而且HOMA-IR与UAER呈独立相关(r=0.4875,P<0.01)。结论:与DM-NA相比,DM-MA有更严重的IR,IR是MA尿的独立危险因素。
36 patients with type 2 diabetes mellitus with microalbuminuria (DM-MA), 29 patients without microalbuminuria (DM-NA) and 20 patients with normal control group (NC). Fasting blood glucose, insulin and lipids were measured in 3 groups. HOMA-IR was used to evaluate the tissue insulin resistance. According to the results, the urinary albumin excretion rate (UAER) and related factors were all analyzed by multiple regression analysis. Results: The HOMA-IR of DM-MA group and DM-NA group were significantly higher than that of NC group (P <0.01). HOMA-IR in DM-MA group was significantly higher than that in DM-NA group Moreover, HOMA-IR was independently associated with UAER (r = 0.4875, P <0.01). Conclusion: Compared with DM-NA, DM-MA has more serious IR, IR is an independent risk factor for urinary MA.