论文部分内容阅读
目的:探讨四妙散结合塞来昔布口服治疗急性痛风性关节炎的临床有效性和安全性。方法:对于120例痛风伴有高尿酸血症患者进行随机双盲对照研究,病例分为两组:治疗组和对照组,每组60例。治疗组患者给予四妙散结合塞来昔布口服,对照组患者给予双氯芬酸纳口服。疗程均为3周,治疗前后检测(UA)血尿酸,(ESR)血沉等指标,并记录临床症状的变化,进行分析比较。结果:治疗组和对照组的临床症状均有改善,两组在治疗后UA和ESR均有明显降低(P<0.05),治疗组患者总有效率98.3%,对照组患者总有效率91.6%;两组比较差异有统计学意义,四妙散结合塞来昔布胶囊口服临床疗效优于单纯口服西药双氯芬酸钠。结论:医院自制中药制剂四妙散联合西药塞来昔布口服是治疗急性痛风性关节炎其中一种行之有效的方法,临床效果明显,值得在临床上推广使用。
Objective: To investigate the clinical efficacy and safety of Si Miao San combined with celecoxib oral in the treatment of acute gouty arthritis. Methods: A randomized, double-blind controlled study of 120 gout patients with hyperuricemia was divided into two groups: treatment group and control group, with 60 cases in each group. Patients in the treatment group were given Si Miao San combined with celecoxib orally, and patients in the control group were given diclofenac orally. The course of treatment was 3 weeks. UA, ESR and ESR before and after treatment were recorded. The changes of clinical symptoms were recorded and analyzed. Results: The clinical symptoms of both treatment group and control group were improved. The UA and ESR of the two groups were significantly decreased after treatment (P <0.05). The total effective rate was 98.3% in the treatment group and 91.6% in the control group. The difference between the two groups was statistically significant, Si Miao San combined with celecoxib oral clinical efficacy is superior to simple oral drug diclofenac sodium. Conclusion: It is an effective method for the treatment of acute gouty arthritis that the traditional Chinese medicine preparation Simiao San combined with western medicine celecoxib is taken orally. The clinical effect is obvious and it is worth to be popularized in clinic.