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用免疫组化法对 5 2例宫颈癌和食管癌标本中P53 基因蛋白过表达进行研究 ,并探讨其与放疗效果的关系。结果显示 ,P53 基因在宫颈癌和食管癌中过表达分别为 35 .48%和 5 2 .38% ;P53 蛋白过表达率在高分化鳞癌中较中低分化者低 (P <0 .0 5 ) ,而与病期无关。在宫颈鳞癌 ,P53 蛋白过表达者 ,近期放疗效果较差 (P <0 .0 5 ) ,食管鳞癌P53 蛋白过表达不同与放疗效果差异无显著性 (P >0 .0 5 ) ,提示P53 基因与放射敏感性有一定关系 ,但不是唯一因素 ,值得进一步研究
Immunohistochemistry was used to study the overexpression of P53 gene protein in 52 specimens of cervical cancer and esophageal cancer, and its relationship with radiotherapy effect was discussed. The results showed that overexpression of P53 gene in cervical cancer and esophageal cancer were 35.48% and 52.38%, respectively; P53 protein overexpression rate was lower in well-differentiated squamous cell carcinoma than in moderately poorly differentiated (P <0. 5), and not related to the disease period. In cervical squamous cell carcinoma, overexpression of P53 protein, the effect of recent radiotherapy was poor (P < 0.05). There was no significant difference in P53 protein overexpression between esophageal squamous cell carcinoma and radiotherapy (P > 0.05). P53 gene has a certain relationship with radiosensitivity, but it is not the only factor that deserves further study.