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目的:研究环氧化酶—2(COX—2)与蛋白酪氨酸磷酸酶基因(PTEN)在各级脑胶质瘤中的表达阳性率与脑胶质瘤病理分级的关系,以及COX—2与PTEN之间的关系。方法:利用免疫组化SP法检测46例脑胶质瘤手术中标本中COX—2与PTEN的表达水平,并比较二者的相关性。结果:随着脑胶质瘤病理级别的升高,COX—2的表达阳性率分别为Ⅰ级15.38%,Ⅱ级33.33%,Ⅲ级70.00%,Ⅳ级87.50%。PTEN的表达阳性率分别为Ⅰ级53.85%,Ⅱ级46.67%,Ⅲ级30.00%,Ⅳ级0.00%。并且将样本分为低级别组合高级别组,二者之间的差别具有统计学意义(P﹤0.05)。结论:COX—2与PTEN的表达对判断胶质瘤的病理分级及开展临床新的治疗方法有一定的意义。
Objective: To investigate the relationship between the expression of cyclooxygenase-2 (COX-2) and protein tyrosine phosphatase (PTEN) in all grades of gliomas and the pathological grade of gliomas, 2 and the relationship between PTEN. Methods: The expression of COX-2 and PTEN in 46 cases of gliomas were detected by immunohistochemical SP method, and their correlations were compared. Results: The positive rates of COX-2 expression were 15.38% in grade Ⅰ, 33.33% in grade Ⅱ, 70.00% in grade Ⅲ and 87.50% in grade Ⅳ, as the pathological grade of gliomas increased. The positive rate of PTEN expression was 53.85% in grade Ⅰ, 46.67% in grade Ⅱ, 30.00% in grade Ⅲ and 0.00% in grade Ⅳ. And the samples were divided into low-level group and high-level group, the difference between the two groups was statistically significant (P <0.05). Conclusion: The expressions of COX-2 and PTEN have certain significance for judging the pathological grade of gliomas and developing new clinical treatment methods.