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目的 :探讨转化生长因子β 型受体 ( TGF-βR1)在良性前列腺增生症 ( BPH)组织中表达的意义。方法 :采用免疫组织化学方法研究 TGF- βR1在 31例 BPH组织中的表达。结果 :TGF- βR1在 BPH上皮、间质组织中的表达率显著高于正常前列腺组织 ( P<0 .0 5 )。结论 :TGF- βR1在 BPH组织中表达增高 ,尤其在上皮组织中的过度表达可能影响了 TGF-β对前列腺上皮细胞的抑制作用 ,可能参与了 BPH的病理变化过程。
Objective: To investigate the significance of transforming growth factor β receptor (TGF-βR1) expression in benign prostatic hyperplasia (BPH). Methods: Immunohistochemistry was used to study the expression of TGF-βR1 in 31 cases of BPH. Results: The expression of TGF-βR1 in BPH epithelial and interstitial tissues was significantly higher than that in normal prostate tissue (P <0.05). CONCLUSION: TGF-βR1 is highly expressed in BPH tissues, especially in overexpression of epithelial cells. TGF-β1 may have an inhibitory effect on prostate epithelial cells and may be involved in the pathological changes of BPH.