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目的:探讨3种治疗方法对大骨节病患者血清细胞因子含量的影响。方法:2015年5月，按照《大骨节病诊断》（WS/T 207-2010），在青海省贵德、兴海和班玛县大骨节病病区选取居住时间≥25年、年龄为25~62岁的Ⅰ度及以上大骨节病患者为研究对象。按照治疗方法不同将患者分为3组，第1组（n n = 91）采用塞来昔布+小活络丸（浓缩丸），第2组（n n = 89）采用塞来昔布+壮骨关节丸，第3组（n n = 94）采用塞来昔布+抗骨质增生片，对比分析3组患者治疗后6个月整体治疗效果。采用酶联免疫吸附测定法（ELISA）检测患者治疗前后血清一氧化氮（NO）、肿瘤坏死因子α（TNF-α）、白细胞介素1β（IL-1β）和透明质酸（HA）含量。n 结果:共纳入大骨节病患者274例，年龄为（47.24 ± 18.97）岁，其中男性132例、女性142例。第1、2、3组治疗有效率分别为80.22%（73/91）、77.53%（69/89）、77.66%（73/94），组间比较差异无统计学意义（χn 2 = 0.25，n P > 0.05）。3组患者治疗前后血清NO含量[（149.23 ± 20.61）、（135.88 ± 29.63），（151.33 ± 22.15）、（137.55 ± 31.51），（148.58 ± 24.36）、（134.81 ± 28.53）μmol/L]比较差异有统计学意义（ n t = 2.678、2.403、3.195，n P均 0.05）。n 结论:3种方法治疗大骨节病均取得一定疗效，且能降低血清NO含量，但对TNF-α、IL-1β和HA含量未见明显影响。“,”Objective:To investigate the effects of 3 treatment methods on serum cytokines in Kaschin-Beck disease (KBD) patients.Methods:In May 2015, according to “Diagnosis of Kaschin-Beck disease” (WS/T 207-2010), KBD patients with grade Ⅰ and above who lived in KBD areas of Guide, Xinghai and Banma counties of Qinghai Province for at least 25 years and aged 25 - 62 years old were selected as research subjects. Patients were divided into 3 groups according to different treatment methods. The first group (n n = 91) was treated with Celecoxib + Xiaohuoluo pill (concentrated pill), the second group (n n = 89) was treated with Celecoxib + bone-strengthening joint pill, and the third group (n n = 94) was treated with Celecoxib + anti-osteogenic tablet, and the overall treatment effects of 6 months after treatment of the 3 groups were compared and analyzed. The contents of serum nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β) and hyaluronic acid (HA) in patients before and after treatment were detected by enzyme-linked immunosorbent assay (ELISA).n Results:A total of 274 KBD patients were included, aged (47.24 ± 18.97) years old, including 132 males and 142 females. The treatment effective rates in the first, second and third groups were 80.22% (73/91), 77.53% (69/89) and 77.66% (73/94), respectively, and there was no significant difference between the three groups (χn 2 = 0.25, n P > 0.05). Before and after the treatment, the serum NO contents of the 3 groups [(149.23 ± 20.61), (135.88 ± 29.63), (151.33 ± 22.15), (137.55 ± 31.51), (148.58 ± 24.36), (134.81 ± 28.53) μmol/L] were significantly different ( n t = 2.678, 2.403, 3.195, n P 0.05).n Conclusion:Three treatment methods for treating KBD have achieved certain effects, all the 3 treatment methods have reduced serum NO content and have no significant effect on TNF-α, IL-1β and HA contents.