209名患者以多中心双盲试验比较了双氟尼酸(diflunisal)的不同服法对活动性类风湿性关节炎的疗效和耐受性。摸索一段时间以后,患者随机分为每晚服双氟尼酸500～1000mg(107名),或250～500mg(102名)每日2次两组,均观察4周。上述两种服法对患者白天的疼痛、晨僵、平均握力和红细胞沉降率均能明显改善,具有相似的疗效。而每日1次疗法缓解患者晚 In a multicenter, double-blind trial, 209 patients compared the efficacy and tolerability of diflunisal with different treatments for active rheumatoid arthritis. After groping for some time, the patients were randomly divided into two groups of 500 ~ 1000 mg (100) of diflunisal every night, or 250 ~ 500 mg (102) twice daily for 4 weeks. The two methods of treatment of patients with pain during the day, morning stiffness, average grip and erythrocyte sedimentation rate can be significantly improved, with similar efficacy. And a daily therapy to alleviate patients with late