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青霉素是治疗脑膜炎球菌、淋球菌和非D 型链球菌脑膜炎的首选药物,但其剂量和给药途径尚无一致的看法,而且对人类脑脊液青霉素浓度缺乏对照性的研究。本文作者根据剂量要按照脑脊液内青霉素的杀菌浓度的原理,对24例儿童化脓性脑膜炎用青霉素G 治疗的药理学作了前瞻性研究。24例脑膜炎的致病菌:9例为肺炎球菌,2例为链球菌型 A,13例为脑膜炎球菌。年龄为2周到11岁(平均2.6岁),仅1例小于1月。病人入院后开始用氯霉素(100毫克/公斤/天,分4次静注)和青霉素(25万单位/公斤/天,
Penicillin is the drug of choice for the treatment of meningococcal, gonococcal and non-D streptococcal meningitis, but there is no consensus on the dosage and route of administration, and there is a lack of control over the concentration of penicillin in human cerebrospinal fluid. According to the dose of the author according to the principle of bactericidal concentration of penicillin in cerebrospinal fluid, 24 cases of purulent meningitis in children treated with penicillin G pharmacological prospective study. 24 cases of meningitis pathogens: 9 cases of pneumococci, 2 cases of streptococcal type A, 13 cases of meningococci. The age ranged from 2 weeks to 11 years (mean, 2.6 years), with only 1 less than 1 month. Patients admitted to hospital with chloramphenicol (100 mg / kg / day, intravenous injection 4 times) and penicillin (250,000 units / kg / day,