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1962年Bristol首先提出,乳糜泻可并发小肠恶性淋巴瘤。以后证实癌肿,特别是位于前肠和中肠者,可伴发乳糜泻;约半数为淋巴瘤,其它恶性肿瘤的发生率亦增多。在伯明翰地区,乳糜泻者特别易并发咽及食管癌。最常伴发乳糜泻的淋巴瘤组织形态,以往认为是何杰金氏病或网状细胞肉瘤。近来认为,伴吸收不良的淋巴瘤在分类上应属恶性组织细胞增多症,可因小肠溃疡的临床表现而就诊。乳糜泻的病理诊断标准:远离肿瘤的小肠粘膜有大部或严重的局部绒毛萎缩及隐窝增生。如病者在无麸
In 1962 Bristol first proposed that celiac disease can be complicated by malignant lymphoma of the small intestine. Later confirmed cancer, especially in the foregut and midgut can be associated with celiac disease; about half of lymphoma, the incidence of other malignant tumors also increased. In the Birmingham area, coeliac patients are particularly susceptible to pharyngeal and esophageal cancer. The most common form of lymphoma associated with celiac disease is known as Hodgkin’s disease or reticular cell sarcoma. Recently, lymphoma with malabsorption should be classified as malignant histiocytosis and can be treated for the clinical manifestations of intestinal ulcers. The diagnostic criteria for celiac disease are: most of the small intestine mucosa distal to the tumor or severe local villi atrophy and crypt hyperplasia. If the patient is in bran